CARRS Cohort Study

Noncommunicable Diseases (NCDs), especially diabetes and cardiovascular diseases, pose major health and economic challenges for low-and-middle-income countries in South Asia. These diseases affect South Asians in the economically active age range (25-64 years old), resulting in human capital losses and high medical expenditures. This stifles economic development and perpetuates poverty for many inhabitants of already low- and middle- income countries. NCDs are intimately related to lifestyle factors (e.g., inactivity; tobacco and alcohol use; dietary, stress, and sleep patterns), and are therefore potentially responsive to prevention. The Center for Cardiometabolic Risk Reduction in South Asia (CARRS) Surveillance Study is a community-based health survey project in three of the world’s largest cities (Delhi and Chennia, India and Karachi, Pakistan). The 28,000 participants are surveyed annually for health and quality of life indicators related to non-communicable diseases, particularly diabetes and cardiovascular diseases (e.g., heart attack, stroke, heart failure). The data gathered will enable a greater understanding of lifestyle patterns and disease risks at the individual level, provide valuable data to educate people regarding lifestyle behaviors that preserve health, connect participants to care and preventative services, and describe societal-level trends in health and wellness. This project is intended to have wide-ranging impacts, providing important guidance regarding design and implementation of sustainable healthy living for policy-makers, industry, health care providers, and consumers in a region that is home to one-fifth of the world’s population (over 1.6 billion people). The ultimate goal is to use data to define programs and interventions to prolong good health, extend years of good quality of life, and reduce years lived with disability, while promoting healthier employees and consumers.

List of CARRS Surveillance Research Group's Publications:

  • Irazola V, Gutierrez L, Bloomfield G, Carrillo-Larco R, Dorairaj P, Gaziano T, Levitt NS, Miranda J, Ortiz AB, Steyn K, Wu Y, Xavier D, Yan L, He J, Rubenstein A. Hypertension Prevalence, Awareness, Treatment, and Control in Selected LMIC Communities. Global Heart. 2016;11(1):47-59.
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  • Patel S, Shivashankar R, Ali M, Anjana RM, Deepa M, Kapoor D, Kondal D, Rautela G, Mohan V, Venkat Narayan KM, Kadir MM, Fatmi Z, Prabhakaran D, Tandon N. Is the “South Asian Phenotype” Unique to South Asians?. Global Heart. 2016;11(1):89-96.e3.
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  • Patel S, Ali M, Alam D, Yan L, Levitt N, Bernabe-Ortiz A, Checkley W, Wu Y, Irazola V, Gutierrez L, Rubinstein A, Shivashankar R, Li X, Miranda J, Chowdhury MAH, Siddiquee A, Gaziano T, Kadir M, Prabhakaran D. Obesity and its Relation With Diabetes and Hypertension. Global Heart. 2016;11(1):71-79.e4.
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  • Shen J, Kondal D, Rubinstein A, Irazola V, Gutierrez L, Miranda J, Bernabé-Ortiz A, Lazo-Porras M, Levitt N, Steyn K, Bobrow K, Ali M, Prabhakaran D, Tandon N. A Multiethnic Study of Pre-Diabetes and Diabetes in LMIC. Global Heart. 2016;11(1):61-70.
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  • Carrillo-Larco R, Miranda J, Li X, Cui C, Xu X, Ali M, Alam D, Gaziano, T, Gupta R, Irazola V, Levitt N, Prabhakaran D, Rubinstein A, Steyn K, Tandon N, Xavier D, Wu Y, Yan L. Prevalence of Pragmatically Defined High CV Risk and its Correlates in LMIC. Global Heart. 2016;11(1):27-36.
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  • Gaziano T, Abrahams-Gessel S, Alam S, Alam D, Ali M, Bloomfield G, Carrillo-Larco R, Dorairaj P, Gutierrez L, Irazola V, Levitt N, Miranda J, Bernabe-Ortiz A, Pandya A, Rubinstein A, Steyn K, Xavier D, Yan L. Comparison of Nonblood-Based and Blood-Based Total CV Risk Scores in Global Populations. Global Heart. 2016;11(1):37-46.e2.
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  • Deepa M, Grace M, Binukumar B, Pradeepa R, Roopa S, Khan HM, Fatmi Z, Kadir MM, Naeem I, Ajay VS, Anjana RM, Ali MK, Prabhakaran D, Tandon N, Mohan V, Venkat Narayan KM; CARRS Surveillance Research Group. High burden of prediabetes and diabetes in three large cities in South Asia: The Center for cArdio-metabolic Risk Reduction in South Asia (CARRS) Study. Diabetes Res Clin Pract. 2015 Sep 25. pii: S0168-8227(15)00378-2. doi: 10.1016/j.diabres.2015.09.005. 
  • Berg CJ, Ajay VS, Ali MK, Kondal D, Khan HM, Shivashankar R, Pradeepa R, Mohan D, Fatmi Z, Kadir MM, Tandon N, Mohan V, Narayan KM, Prabhakaran D. A cross-sectional study of the prevalence and correlates of tobacco use in Chennai, Delhi, and Karachi: data from the CARRS study. BMC Public Health. 2015 May 11;15:483. doi: 10.1186/s12889-015-1817-z.
  • Ali MK, Bhaskarapillai B, Shivashankar R, Mohan D, Fatmi ZA, Pradeepa R, Masood Kadir M, Mohan V, Tandon N, Venkat Narayan KM, Prabhakaran D; CARRS investigators. Socioeconomic status and cardiovascular risk in urban South Asia:  The CARRS Study. Eur J Prev Cardiol. 2015 Apr 27. pii: 2047487315580891.
  • Anand S, Shivashankar R, Ali MK, Kondal D, Binukumar B, Montez-Rath ME, Ajay VS, Pradeepa R, Deepa M, Gupta R, Mohan V, Narayan KM, Tandon N, Chertow GM, Prabhakaran D; CARRS Investigators. Prevalence of chronic kidney disease in two major Indian cities and projections for associated cardiovascular disease. Kidney Int. 2015 Jul;88(1):178-85. 
  • Finzer LE, Ajay VS, Ali MK, Shivashankar R, Goenka S, Sharma P, Pillai DS, Khandelwal S, Tandon N, Reddy KS, Narayan KM, Prabhakaran D. Fruit and vegetable purchasing patterns and preferences in South Delhi. Ecol Food Nutr. 2013;52(1):1-20. 
  • Nair M, Ali MK, Ajay VS, Shivashankar R, Mohan V, Pradeepa R, Deepa M, Khan HM, Kadir MM, Fatmi ZA, Reddy KS, Tandon N, Narayan KM, Prabhakaran D. CARRS Surveillance study: design and methods to assess burdens from multiple perspectives. BMC Public Health. 2012 Aug 28;12:701.
  • Mendenhall E, Shivashankar R, Tandon N, Ali MK, Narayan KMV, Prabhakaran D. Stress and Diabetes in Socioeconomic Context: A Qualitative Study of Urban Indians. Soc Sci Med. Dec 2012; 75(12): 2522–2529